For example, you might notice menstrual pain, breast tenderness, nausea, headaches, or spotting. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. In most cases, you should be able to continue consuming grapefruit with birth control without any issues. U.S. Food and Drug Administration (FDA). Mainly, readers wanted to better understand the estrogen effect. This can help with hot flashes, night sweats, mood changes, and many of the other symptoms of perimenopause and menopause. One study looked at how grapefruit juice (containing 887 mg/mL of naringin) affect estrogen levels and compared this to the effect of drinking herbal tea.1 In contrast to herbal tea, grapefruit juice significantly increased peak plasma levels to 137% (Cmax) and the area under plasma concentration-time curve (AUC) from 0 to 8 hours to 128%. may lead to serious health consequences from extra high estrogen levels. DOI: 10.1046/j.1365-2125.1998.00764.x, Grande LA, Mendez RD, Krug RT, et al. In the short-term, after eating a grapefruit or drinking grapefruit juice, you may notice some side effects. Accessed March 9, 2020 at. After reading more about grapefruit's interaction with different medications, we thought we'd pass along the following: First, the compounds in grapefruit can interfere with enzymes in the body that break down estrogen-progestin products and other drugs. The information presented on this web site is not intended to take the place of your personal physician’s advice and is not intended to diagnose, treat, cure or prevent any disease. Have you received a medication at the pharmacy with a sticker that warns to avoid grapefruit or grapefruit juice? When we posted last July about the risk of eating grapefruit when taking certain medications and the potential link to breast cancer in post-menopausal women, we recevied quite a bit of feedback. A possible explanation is that grapefruit juice slows down the break down of ethinylestradiol. Birth control pills work by preventing fertilization of the woman's egg with the man’s sperm. Contraception. However, birth control drug interactions or greater estrogen side effects like breast tenderness or nausea might occur. grapefruit interact with medications like estradiol. Grapefruits can cause serious food-drug interactions. Grapefruits and grapefruit juice affects how your body absorbs certain medications. (Click here to read the original post and a 2013 update.). However, they can only change certain target cells. More rare but serious side effects have been described when estrogen was combined with large quantities of grapefruit. There are some other potential effects of mixing grapefruit with estrogen replacement therapy. However, it’s important to note that researchers are still studying this potential effect. If you’re taking hormones for menopause symptoms, then it may be best to stay away from this citrus. One of these enzymes is the CYP3A4 enzyme, primarily found in your liver and digestive tract. Because grapefruit can interfere with the breakdown of estrogen type drugs, the drug's effect can be greatly pronounced in the body--meaning that the dosage actually received can be multiplied. If there is a recommendation to avoid grapefruit juice, it's best to avoid it completely when you are taking the medication, not just when you swallow your pill. Bioidentical estradiol is an FDA-approved medication for helping relieve menopause symptoms, and this is the hormone replacement treatment we use to help treat low estrogen levels. If you eat grapefruit or drink grapefruit juice, be sure to tell your doctor, pharmacist or other health care provider. These include: This is not a complete list of all drug interactions with birth control. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The Effect of Grapefruit Intake on Endogenous Serum Estrogen Levels in Postmenopausal Women. The FDA requires a warning label about grapefruit and estrogen reactions on all estrogen medications, as it may cause serious side effects. Learn More: Does Birth Control Interact With Alcohol? Cranberry juice has not been shown to interact with birth control, but the blood thinner warfarin (an anticoagulant) has been shown to have an interaction with cranberry. Available for Android and iOS devices. Example of drugs that inhibit 3A4 enzyme activity include: Learn More: Antibiotics and Birth Control Pill Interactions: Fact or Fallacy? The information contained herein is presented in summary form only and intended to provide broad consumer understanding and knowledge. Using these medications together can cause you to bleed more easily. Clinically relevant drug interactions with grapefruit juice can occur, so always check with your doctor for the impact. Three days after starting the grapefruit diet, she experienced an acute venous thrombosis (a serious blood clot in a deep vein of the leg) and the authors theorize it may have been in part due to the interaction of the grapefruit, enzyme inhibition, and the estrogen in the birth control pill leading to enhanced risk of a blood clot.7. This product usually comes from the winemaking process and is, in large part, a byproduct. Estradiol is the more potent form of the hormone, and the National Institute of Health deems it the most form of estrogen in a woman’s body. Many drugs may alter enzyme activity and increase estrogen levels and side effects, or decrease estrogen levels which can lower birth control effectiveness. A common question we hear is, “what if I just limit how much grapefruit I eat?” Others wonder if it’s okay to drink grapefruit juice so long as it’s not on days when they receive their hormone injection. Does when you eat or drink grapefruit affect your birth control? Long-term effects may have serious consequences for your health. This shouldn't lower the effectiveness of your birth control, but it might increase the chances for side effects like breast tenderness, nausea, changes in uterine bleeding, blood clots, or breast cancer. More serious side effects like blood clots or an increased risk of breast cancer are theoretical concerns, too (but not proven). At HerKare, we provide quality, compassionate health care for women. Always check with your doctor or pharmacist for clinically significant drug interactions. Accessed March 13, 2020. In fact, most of the studies done on grapefruit-drug interactions were based on just one glass of grapefruit juice per day. Unfortunately, even small amounts of grapefruit can affect your estrogen levels. Let them know how much grapefruit you consume each day. Do not stop medications on your own without checking with your doctor or other healthcare provider. Grapefruit and Birth Control Pills: Your Questions Answered, We comply with the HONcode standard for trustworthy health information -. Select one or more newsletters to continue. Whether naturally produced or as part of your estrogen replacement therapy regimen, estrogens work by binding to estrogen receptors in cells in your body. Clarifying the grapefruit concern about estrogen levels, Click here to read the original post and a 2013 update, grapefruit interacts with over 60% of orally administered drugs, REAL Tesla Competition: Lucid and Polestar. You may need to use an additional (back-up) form of birth control like condoms while using the enzyme inducer and for one cycle after you stop taking the inducer. In contrast, fresh grapefruit juice, bottled grapefruit juice, and grapefruit soda intake all had significant lowering effects on estradiol. Grapefruit, grapefruit juice and birth control combined decrease the activity of the enzymes that break down estrogen, leading to the higher blood levels of estrogen. While grapefruits do have their positive effects, it’s important to understand that it may cause a drug-food interaction with. An estimated 21% of American households purchase grapefruit juice, with many more eating the fruit whole. The information should not be considered complete and should not be used in place of a visit, call, consultation or advice of your physician or other health care provider. 2017;8:420. Lines and paragraphs break automatically. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. However, some researchers warn against consuming grapefruits with progesterone due to the potentially similar effects. Our medical professionals take the time to listen to how you’re feeling and the symptoms you’re experiencing. Grapefruit juice may increase your risk for experiencing side effects from your hormone imbalance treatment. Another study saw that estrogen levels increased significantly after eating just ½ a grapefruit per day. THE HERKARE LOGO AND MARKS ARE REGISTERED TRADEMARKS OF HER KARE HOLDINGS, LLC. As reported in a study by Monroe4 taking medications and grapefruit or grapefruit juice at different times may not lessen the possibility for an interaction. When grapefruit and the pill are consumed, blood levels of estrogen may rise, resulting in a risk for new or worsened. Fourth, one potential solution is using a skin patch, which bypasses the whole digestive process that grapefruit impacts. Can grapefruit juice influence ethinylestradiol bioavailability? It may also make medications stay in the body longer. It may also make medications stay in the body longer. Inducers of CYP3A4 may reduce plasma concentrations of estrogens. Last updated on Mar 13, 2020. A study in 59 women found that eating grapefruit can increase levels of endogenous estrogen (but not grapefruit juice and estrogen).4 The results showed that whole grapefruit intake had significant effects on endogenous estrone-3-sulfate. In many cases, this may increase the amount of medication that goes into your bloodstream. If you’re taking hormones for menopause symptoms, then it may be best to stay away from this citrus. Many of these side effects have not been proven with grapefruit, but theoretically may occur. See a list of other popular birth control options. Discuss this information with your own physician or healthcare provider to determine what is right for you. Etoposide interferes with grapefruit, orange, and apple juices. This can help with hot flashes, night sweats, mood changes, and many of the other symptoms of perimenopause and menopause. Learn More: What are the benefits compared to the risks of taking birth control pills?